2 edition of Some responses of rat lung to inhaled glass fibres. found in the catalog.
Some responses of rat lung to inhaled glass fibres.
Colin John Hardy
Thesis(Ph.D.) - University of East Anglia, School of Biological Sciences, 1981.
Section 1 Experimental pathology studies with rats, including lung dose determination studies. These studies on the pathological responses of rats to following inhalation of fibres or particles and were aimed at determining the types of pathological response and the important characteristics of fibres and particles that dictate their : Kenneth Donaldson. Some invertebrates have lung-like structures that serve a similar respiratory purpose as, but are not evolutionarily related to, vertebrate lungs. Some arachnids, such as spiders and scorpions, have structures called book lungs used for atmospheric gas exchange. Some species of spider have four pairs of book lungs but most have two : D
Biopersistence and Durability of Nine Mineral Fibre Types in Rat Lungs over 12 Months The link between biopersistence of inhaled ﬁbres and risk of pathological response in the lung is widely accepted (Davis, ), although reliable some ﬁbre types from lung tissue (Davis, ; Eastes and Hadley, ; Searl, ), and therefore. 1. adenocarcinoma (~40% of cases) originates in peripheral lung areas- bronchial glands, alveolar cells 2. squamous cell carcinoma (% of cases) in bronchial epithelium 3. small cell carcinoma (~20% of cases) contains lymphocyte-like cells that originate in primary bronchi and subsequently metastasize.
Pay Attention to Books' Deadly Dust. Relationship of Lung Cancer and Heart Attack to Library Books' Dust. By Hassan Bolourchi, Ph.D. [email protected] This article is presented at: The 6th edition of the Indoor Air Quality Meeting (IAQ) in Padova, Italy. 10 to 12 November The durability of fibres deposited in the lung is dependent upon the lung’s ability to clear the fibres, as well as the fibres’ physical and chemical properties. The durability of man-made fibres can be altered in the production process, according to end-use requirements, through the addition of certain stabilizers such as Al 2 O 3.
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Sized glass fibres were administered to rats by intratracheal instillation to study the effect of fibre length and diameter on clearance and also on the solubility of fibres in the lung.
Deposition, clearance, retention, and durability of inhaled particles in lung are important factors for induction of pulmonary fibrosis or lung cancer.
To study the deposition and clearance of aluminium silicate ceramic fibers from the lung, male Wistar rats were exposed to ceramic fibers, with a mass median aerodynamic diameter (MMAD) of Cited by: 4.
The distribution of inhaled mineral fibers in the lung determines the site and severity of disease caused by the fibers. Some of our recent work has described the fate of inhaled asbestos fibers in rodents.
After a brief inhalation exposure, asbestos fibers are deposited primarily at the first alveolar duct bifurcations, and fibrotic lesions Cited by: Influence of characteristics of inhaled fibres on development of tumours in the rat lung.
and other cell responses to fibres in vitro. Despite the small number of data points, the results. Sized glass fibres were administered to rats by intratracheal instillation to study the effect of fibre length and diameter on clearance and also on the solubility of fibres in the lung. The samples included 5, 10, 30 and 60 × μm and 10 and 60 × 3 μm by: lung more easily than others and some are more readily removed than others.
In this study the lungs of baboons which had been exposed to different types of fibre were examined and the build up of fibres in the lung after different periods of exposure plotted.
Similarly the clearance of fibres from the lung after exposure was determined. Schematic diagram of the exposure system. Deposition of inhaled man-made mineral fibres in the lungs of rats Determination of fibre content in lung tissue Lungs from each rat were ashed in a low temperature asher at W radio frequency (RF) forward, 5 W RF reflected and 5 cm3 min"1 for theflowrate of by: Inhaled Particles VI In contrast, addition of EDTA to LP reduced only some toxic responses (oedema, bleeding, and inhibition of macrophage phagocytosis).
Thus, metals play a greater role in the toxicity of L than of LP. of fibres added to non-exposed lung rat tissue, and of fibres recovered from exposed lung tissue 5, 30, 90, and. It illustrates the movement of fibers within the respiratory tract, specific responses to mediators and several recognized biological responses to fibers, in particular asbestos fibers, i.e.,bronchial carcinoma, pleural mesothelioma and lung fibrosis.
It should be noted that Cited by: 4. In some circumstances the dust may be inhaled on a single occasion (which is often the concern with, for example, considerably lower for lung burdens B above some critical level.
Thesefindings formed the basis for the distributions for fibres recovered after three, six, 12, 15, and 18 months of exposure respectively. ThisCited by: Abstract. The present study was designed to determine whether pleural fiber burdens or subchronic pleural fibroproliferative and inflammatory changes can help explain the marked interspecies differences in pleural fibrosis and mesothelioma that are observed following long-term inhalation of RCF-1 ceramic fibers by rats and by: Multi-walled carbon nanotubes (MWCNTs) constitute one of the most promising types of nanomaterials in industry today.
With their increasing use, the potential toxicity and carcinogenicity of MWCNT needs to be evaluated in bioassay studies using rodents. Since humans are mainly exposed to MWCNT by inhalation, we performed a week carcinogenicity study using whole-body inhalation Cited by: The Effects of Lead Inhalation on Rat Lung Morphology lymphocytes and macrophages were observed in the bronchioli and bronchi lumina, alveoli lumina and interalveolar septa.
Fibrosis and bronchopneumonia appeared to have occurred following lead administration (Figure 6). There was no evidence of bronchopneumonia in the rest of the group.
9/7/ DISSOLUTION OF GLASS FIBERS IN THE RAT LUNG FOLLOWING INTRATRACHEAL INSTILLATION neutral pH resembled those in the rat lung. Glass ﬁbers of ﬁve different compositions were followed after intratracheal instillation in and some associated statistical parameters, are given in.
Miller BG, Jones AD, Searl A, Buchanan D, Cullen RT, Soutar CA, et al. Influence of characteristics of inhaled fibres on development of tumours in the rat lung. Ann Occup Hyg ;43(3) Lippmann M.
Deposition and retention of inhaled fibres: effects on incidence of lung cancer and mesothelioma. The lungs of patients suffering chronic obstructive pulmonary disease (COPD) attempt to repair damaged elastic fibers, a new finding that contradicts the conventional wisdom on the capabilities of.
The exact role of primary nanoparticle (NP) size and their degree of agglomeration in aerosols on the determination of pulmonary effects is still poorly understood. Smaller NP are thought to have greater biological reactivity, but their level of agglomeration in an aerosol may also have an impact on pulmonary response.
The aim of this study was to investigate the role of primary NP size and Cited by: In some cases, the results are used in attempts to develop quantitative estimates of human lung cancer risk.
This report reviews evidence for the usefulness of the rat for evaluation of lung cancer hazards from inhaled particles. Milne, James.
"Are glass fibres carcinogenic to man. A critical appraisal.". not decrease. The interim results suggest that inhaled cellulose fibres have slow clearance, but do not produce sustained pulmonary inflammatory effects after exposure has terminated. Contrary to p-aramid, cellulose fibres do not react with components of lung fluids and are not shortened through enzymatic digestion.
They induce a significantFile Size: KB. lung condition usually caused by trauma, pneumonia, smoke or fumes, inhaled vomit, or sepsis (systemic bacterial infection in the blood stream) -life-threatening condition in which inflammation in the lungs and fluid in the alveoli lead to low levels of oxygen in the blood.
Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Weixel on does fiberglass insulation cause lung cancer: Asbestos exposure has been shown to be related to squamous cell carcinoma, but is best known for mesothelioma.
Any type of carcinoma is possible. for topic: Does Fiberglass Insulation Cause Lung Cancer.A multiple-path model of fiber deposition in the rat lung developed by Asgharian and Anjilvel () indicated that in oral airways, where deposition is mainly by impaction, the larger the fiber aspect exposed F rats to chrysotile asbestos fibers at 10 mg/m 3 as a positive control for comparison with responses to glass fibers.
At the end.Rat lungworm disease can devastate lives By Kay Howe Wednesday, Janu AM HST I'd been five months in the rainforest in Kalimantan on the island of Borneo working with my Dayak and Melayu friends on an organic farming and wild forest honeybee project when I got the text message: "Graham (McCumber) (my son) is sick.
Lyn (my sister File Size: KB.